High-Throughput Screening Identifies Kinase Inhibitors That Increase Dual Adeno-Associated Viral Vector Transduction In Vitro and in Mouse Retina

Retinal gene therapy based on adeno-associated viral (AAV) vectors is safe and efficient in humans. The low intrinsic DNA transfer capacity of AAV has been expanded by dual vectors where a large expression cassette is split in two halves independently packaged in two AAV vectors. Dual AAV transducti...

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Detalles Bibliográficos
Autores principales: Maddalena, Andrea, Dell'Aquila, Fabio, Giovannelli, Pia, Tiberi, Paola, Wanderlingh, Luca Giorgio, Montefusco, Sandro, Tornabene, Patrizia, Iodice, Carolina, Visconte, Feliciano, Carissimo, Annamaria, Medina, Diego Luis, Castoria, Gabriella, Auricchio, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098407/
https://www.ncbi.nlm.nih.gov/pubmed/29641320
http://dx.doi.org/10.1089/hum.2017.220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098407/
https://www.ncbi.nlm.nih.gov/pubmed/29641320
http://dx.doi.org/10.1089/hum.2017.220

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