Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence

BACKGROUND: Dormant estrogen receptor positive (ER+) breast cancer micrometastases in the bone marrow survive adjuvant chemotherapy and recur stochastically for more than 20 years. We hypothesized that inflammatory cytokines produced by stromal injury can re-awaken dormant breast cancer cells. METHO...

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Detalles Bibliográficos
Autores principales: Tivari, Samir, Lu, Haiyan, Dasgupta, Tanya, De Lorenzo, Mariana S., Wieder, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098600/
https://www.ncbi.nlm.nih.gov/pubmed/30119678
http://dx.doi.org/10.1186/s12964-018-0259-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098600/
https://www.ncbi.nlm.nih.gov/pubmed/30119678
http://dx.doi.org/10.1186/s12964-018-0259-5

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