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Activation of Phosphotyrosine-Mediated Signaling Pathways in the Cortex and Spinal Cord of SOD1(G93A), a Mouse Model of Familial Amyotrophic Lateral Sclerosis

Degeneration of cortical and spinal motor neurons is the typical feature of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease for which a pathogenetic role for the Cu/Zn superoxide dismutase (SOD1) has been demonstrated. Mice overexpressing a mutated form of the SOD1 gene...

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Detalles Bibliográficos
Autores principales: Mallozzi, Cinzia, Spalloni, Alida, Longone, Patrizia, Domenici, Maria Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098854/
https://www.ncbi.nlm.nih.gov/pubmed/30154836
http://dx.doi.org/10.1155/2018/2430193