Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways

Background: Increased permeability of pulmonary capillary is a common consequence of sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor (UTI), is used clinically to mitigate pulmonary edema caused by sepsis. However, the underlying mechanism of UTI i...

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Detalles Bibliográficos
Autores principales: Fang, Ming, Zhong, Wen-hong, Song, Wen-liang, Deng, Yi-yu, Yang, Duo-meng, Xiong, Bin, Zeng, Hong-ke, Wang, Hua-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099086/
https://www.ncbi.nlm.nih.gov/pubmed/30150933
http://dx.doi.org/10.3389/fphar.2018.00823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099086/
https://www.ncbi.nlm.nih.gov/pubmed/30150933
http://dx.doi.org/10.3389/fphar.2018.00823

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