Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury

Acetaminophen (paracetamol‐APAP) is the most common cause of drug‐induced liver injury in the Western world. Reactive metabolite production by cytochrome P450 enzymes (CYP‐metabolites) causes hepatotoxicity. We explored the toxicokinetics of human circulating APAP metabolites following overdose. Pla...

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Detalles Bibliográficos
Autores principales: Vliegenthart, ADB, Kimmitt, RA, Seymour, JH, Homer, NZ, Clarke, JI, Eddleston, M, Gray, A, Wood, DM, Dargan, PI, Cooper, JG, Antoine, DJ, Webb, DJ, Lewis, SC, Bateman, DN, Dear, JW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099202/
https://www.ncbi.nlm.nih.gov/pubmed/27770431
http://dx.doi.org/10.1002/cpt.541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099202/
https://www.ncbi.nlm.nih.gov/pubmed/27770431
http://dx.doi.org/10.1002/cpt.541

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