Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease

The overwhelming majority of dominant mutations causing early onset familial Alzheimer’s disease (EOfAD) occur in only three genes, PSEN1, PSEN2, and APP. An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies...

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Detalles Bibliográficos
Autores principales: Lumsden, Amanda L., Rogers, Jack T., Majd, Shohreh, Newman, Morgan, Sutherland, Greg T., Verdile, Giuseppe, Lardelli, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099262/
https://www.ncbi.nlm.nih.gov/pubmed/30150923
http://dx.doi.org/10.3389/fnins.2018.00533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099262/
https://www.ncbi.nlm.nih.gov/pubmed/30150923
http://dx.doi.org/10.3389/fnins.2018.00533

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