Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line

Regulatory guidelines require the sponsors to provide assurance of clonality of the production cell line, and when such evidence is not available, additional studies are typically required to further ensure consistent long‐term manufacturing of the product. One potential approach to provide such ass...

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Detalles Bibliográficos
Autores principales: Tharmalingam, Tharmala, Barkhordarian, Hedieh, Tejeda, Nicole, Daris, Kristi, Yaghmour, Sam, Yam, Pheng, Lu, Fang, Goudar, Chetan, Munro, Trent, Stevens, Jennitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099272/
https://www.ncbi.nlm.nih.gov/pubmed/29882350
http://dx.doi.org/10.1002/btpr.2666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099272/
https://www.ncbi.nlm.nih.gov/pubmed/29882350
http://dx.doi.org/10.1002/btpr.2666

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