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Integrative Analysis of Proteome and Ubiquitylome Reveals Unique Features of Lysosomal and Endocytic Pathways in Gefitinib‐Resistant Non‐Small Cell Lung Cancer Cells

Non‐small cell lung cancer (NSCLC) patients carrying EGFR activating mutations treated with gefitinib, a tyrosine kinase inhibitor, will develop drug resistance. Ubiquitylation is one of major posttranslational modifications of proteins affecting the stability or function of proteins. However, the r...

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Detalles Bibliográficos
Autores principales: Li, Wang, Wang, Heyong, Yang, Yan, Zhao, Tian, Zhang, Zhixiong, Tian, Ye, Shi, Zhaomie, Peng, Xiaojun, Li, Fei, Feng, Yonghong, Zhang, Lei, Jiang, Gening, Zhang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099292/
https://www.ncbi.nlm.nih.gov/pubmed/29901268
http://dx.doi.org/10.1002/pmic.201700388