MMP7 cleaves remyelination‐impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions

Upon demyelination, transient expression of fibronectin precedes successful remyelination. However, in chronic demyelination observed in multiple sclerosis (MS), aggregates of fibronectin persist and contribute to remyelination failure. Accordingly, removing fibronectin (aggregates) would constitute...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Gorter, Rianne P., de Jonge, Jenny C., Nazmuddin, Muhammad, Zhao, Chao, Amor, Sandra, Hoekstra, Dick, Baron, Wia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099312/
https://www.ncbi.nlm.nih.gov/pubmed/29600597
http://dx.doi.org/10.1002/glia.23328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099312/
https://www.ncbi.nlm.nih.gov/pubmed/29600597
http://dx.doi.org/10.1002/glia.23328

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