Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidity

There is strong interest in the production of bispecific monoclonal antibodies that can simultaneously bind two distinct targets or epitopes to achieve novel mechanisms of action and efficacy. Regeneron's bispecific technology, based upon a standard IgG, consists of a heterodimer of two differe...

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Detalles Bibliográficos
Autores principales: Tustian, Andrew D., Laurin, Linus, Ihre, Henrik, Tran, Travis, Stairs, Robert, Bak, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099419/
https://www.ncbi.nlm.nih.gov/pubmed/29464924
http://dx.doi.org/10.1002/btpr.2622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099419/
https://www.ncbi.nlm.nih.gov/pubmed/29464924
http://dx.doi.org/10.1002/btpr.2622

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