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Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidity
There is strong interest in the production of bispecific monoclonal antibodies that can simultaneously bind two distinct targets or epitopes to achieve novel mechanisms of action and efficacy. Regeneron's bispecific technology, based upon a standard IgG, consists of a heterodimer of two differe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099419/ https://www.ncbi.nlm.nih.gov/pubmed/29464924 http://dx.doi.org/10.1002/btpr.2622 |