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Spared CA1 pyramidal neuron function and hippocampal performance following antisense knockdown of microRNA‐134
OBJECTIVE: Inhibition of microRNA‐134 by an oligonucleotide antagomir (ant‐134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess what potential adverse effects it may have...
Autores principales: | Morris, Gareth, Brennan, Gary P., Reschke, Cristina R., Henshall, David C., Schorge, Stephanie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099438/ https://www.ncbi.nlm.nih.gov/pubmed/29978460 http://dx.doi.org/10.1111/epi.14475 |
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