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Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation

The protein kinase D (PKD) family is regulated through multi‐site phosphorylation, including autophosphorylation. For example, PKD displays in vivo autophosphorylation on Ser‐742 (and Ser‐738 in vitro) in the activation loop and Ser‐910 in the C‐tail (hPKD1 numbering). In this paper, we describe the...

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Detalles Bibliográficos
Autores principales: Cobbaut, Mathias, Derua, Rita, Parker, Peter J., Waelkens, Etienne, Janssens, Veerle, Van Lint, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099456/
https://www.ncbi.nlm.nih.gov/pubmed/29933512
http://dx.doi.org/10.1002/1873-3468.13171