Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway

A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity; (ii) a 12-N-benzyl moiety was favorable for acti...

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Detalles Bibliográficos
Autores principales: Niu, Tianyu, Niu, Weixiao, Bao, Yunyang, Liu, Ting, Song, Danqing, Li, Yinghong, He, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099493/
https://www.ncbi.nlm.nih.gov/pubmed/29976890
http://dx.doi.org/10.3390/molecules23071644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099493/
https://www.ncbi.nlm.nih.gov/pubmed/29976890
http://dx.doi.org/10.3390/molecules23071644

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