Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

The inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) potentially represents a new treatment option for malaria, as P. falciparum relies entirely on a de novo pyrimidine biosynthetic pathway for survival. Herein, we report a series of pyrimidone derivatives as novel inhibito...

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Detalles Bibliográficos
Autores principales: Xu, Le, Li, Wenjie, Diao, Yanyan, Sun, Hongxia, Li, Honglin, Zhu, Lili, Zhou, Hongchang, Zhao, Zhenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099574/
https://www.ncbi.nlm.nih.gov/pubmed/29794978
http://dx.doi.org/10.3390/molecules23061254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099574/
https://www.ncbi.nlm.nih.gov/pubmed/29794978
http://dx.doi.org/10.3390/molecules23061254

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