A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development

Zebrafish is the preferred vertebrate model for high throughput chemical screens to discover modulators of complex biological pathways. We adapted a transgenic zebrafish line, Tg(dusp6:EGFP), which reports on fibroblast growth factor (Fgf)/Ras/Mapk activity, into a quantitative, high-content chemica...

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Detalles Bibliográficos
Autores principales: Saydmohammed, Manush, Vollmer, Laura L., Onuoha, Ezenwa O., Maskrey, Taber S., Gibson, Gregory, Watkins, Simon C., Wipf, Peter, Vogt, Andreas, Tsang, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099644/
https://www.ncbi.nlm.nih.gov/pubmed/29997348
http://dx.doi.org/10.3390/molecules23071691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099644/
https://www.ncbi.nlm.nih.gov/pubmed/29997348
http://dx.doi.org/10.3390/molecules23071691

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