Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles

The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB...

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Detalles Bibliográficos
Autores principales: Lorca, Marcos, Morales-Verdejo, Cesar, Vásquez-Velásquez, David, Andrades-Lagos, Juan, Campanini-Salinas, Javier, Soto-Delgado, Jorge, Recabarren-Gajardo, Gonzalo, Mella, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099677/
https://www.ncbi.nlm.nih.gov/pubmed/29772697
http://dx.doi.org/10.3390/molecules23051191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099677/
https://www.ncbi.nlm.nih.gov/pubmed/29772697
http://dx.doi.org/10.3390/molecules23051191

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