(-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones

We describe the syntheses of nine new angucyclinone 6-aza-analogues, achieved through a hetero Diels-Alder reaction between the shikimic acid derivative-azadiene 13, with different naphthoquinones. The cytotoxic activity of the new synthesized compounds and five angucyclinones, previously reported,...

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Detalles Bibliográficos
Autores principales: Quiñones, Natalia, Hernández, Santiago, Espinoza Catalán, Luis, Villena, Joan, Brito, Ivan, Cabrera, Alan R., Salas, Cristian O., Cuellar, Mauricio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099682/
https://www.ncbi.nlm.nih.gov/pubmed/29895756
http://dx.doi.org/10.3390/molecules23061422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099682/
https://www.ncbi.nlm.nih.gov/pubmed/29895756
http://dx.doi.org/10.3390/molecules23061422

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