Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures

Lysine-specific demethylase 1 (LSD1) mainly removes methyl groups of mono- or di-methylated lysine residues at the fourth position of histone H3 to epigenetically regulate the expression of genes associated with several diseases, such as cancer. Therefore, LSD1 inactivators are expected to be used a...

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Detalles Bibliográficos
Autores principales: Ota, Yosuke, Kakizawa, Taeko, Itoh, Yukihiro, Suzuki, Takayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099693/
https://www.ncbi.nlm.nih.gov/pubmed/29734782
http://dx.doi.org/10.3390/molecules23051099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099693/
https://www.ncbi.nlm.nih.gov/pubmed/29734782
http://dx.doi.org/10.3390/molecules23051099

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