Design, Synthesis and Biological Evaluation of 6,7-Disubstituted-4-phenoxyquinoline Derivatives Bearing Pyridazinone Moiety as c-Met Inhibitors

Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, a series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing pyridazinone derivative...

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Detalles Bibliográficos
Autores principales: Liu, Xiaobo, Kou, Jianlan, Xiao, Zhen, Tian, Fajuan, Hu, Jiayi, Zheng, Pengwu, Zhu, Wufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099740/
https://www.ncbi.nlm.nih.gov/pubmed/29949931
http://dx.doi.org/10.3390/molecules23071543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099740/
https://www.ncbi.nlm.nih.gov/pubmed/29949931
http://dx.doi.org/10.3390/molecules23071543

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