New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro

P-glycoprotein (Pgp) determines resistance to a broad spectrum of drugs used against glioblastoma multiforme (GB). Indeed, Pgp is highly expressed in GB stem cells and in the brain-blood barrier (BBB), the peculiar endothelium surrounding the brain. Inhibiting Pgp activity in the BBB and GB is still...

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Detalles Bibliográficos
Autores principales: Salaroglio, Iris Chiara, Gazzano, Elena, Kopecka, Joanna, Chegaev, Konstantin, Costamagna, Costanzo, Fruttero, Roberta, Guglielmo, Stefano, Riganti, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099747/
https://www.ncbi.nlm.nih.gov/pubmed/29890725
http://dx.doi.org/10.3390/molecules23061401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099747/
https://www.ncbi.nlm.nih.gov/pubmed/29890725
http://dx.doi.org/10.3390/molecules23061401

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