Cargando…

New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro

P-glycoprotein (Pgp) determines resistance to a broad spectrum of drugs used against glioblastoma multiforme (GB). Indeed, Pgp is highly expressed in GB stem cells and in the brain-blood barrier (BBB), the peculiar endothelium surrounding the brain. Inhibiting Pgp activity in the BBB and GB is still...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salaroglio, Iris Chiara, Gazzano, Elena, Kopecka, Joanna, Chegaev, Konstantin, Costamagna, Costanzo, Fruttero, Roberta, Guglielmo, Stefano, Riganti, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099747/ https://www.ncbi.nlm.nih.gov/pubmed/29890725 http://dx.doi.org/10.3390/molecules23061401

Ejemplares similares

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
por: Gazzano, Elena, et al.
Publicado: (2018)

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2014)

ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer
por: Salaroglio, Iris C., et al.
Publicado: (2019)

Overcoming drug resistance in glioblastoma: new options in sight?
por: Kopecka, Joanna, et al.
Publicado: (2021)

Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma
por: Hattinger, Claudia Maria, et al.
Publicado: (2023)

Naked and Decorated Nanoparticles Containing H(2)S-Releasing Doxorubicin: Preparation, Characterization and Assessment of Their Antitumoral Efficiency on Various Resistant Tumor Cells
por: Peira, Elena, et al.
Publicado: (2022)

Use of Enzymatically Activated Carbon Monoxide Donors for Sensitizing Drug-Resistant Tumor Cells
por: Sodano, Federica, et al.
Publicado: (2023)

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
por: Salaroglio, Iris C., et al.
Publicado: (2018)

Plant-Derived Trans-β-Caryophyllene Boosts Glucose Metabolism and ATP Synthesis in Skeletal Muscle Cells through Cannabinoid Type 2 Receptor Stimulation
por: Geddo, Federica, et al.
Publicado: (2021)

P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
por: Kopecka, Joanna, et al.
Publicado: (2016)

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor
por: Riganti, Chiara, et al.
Publicado: (2020)

Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
por: Akman, Muhlis, et al.
Publicado: (2021)

Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors
por: Campani, Virginia, et al.
Publicado: (2022)

Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer
por: Salaroglio, Iris C., et al.
Publicado: (2022)

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
por: Salaroglio, Iris C., et al.
Publicado: (2017)

Targeting Mitochondrial Oncometabolites: A New Approach to Overcome Drug Resistance in Cancer
por: Godel, Martina, et al.
Publicado: (2021)

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
por: Kopecka, Joanna, et al.
Publicado: (2016)

Combination of PDT and NOPDT with a Tailored BODIPY Derivative
por: Lazzarato, Loretta, et al.
Publicado: (2019)

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells
por: Kopecka, Joanna, et al.
Publicado: (2015)

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells
por: Campia, Ivana, et al.
Publicado: (2015)

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells
por: De Boo, Sara, et al.
Publicado: (2009)

Neuronal Activity, Mitogens, and mTOR: Overcoming the Hurdles for the Treatment of Glioblastoma Multiforme
por: Maiese, Kenneth
Publicado: (2015)

Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models
por: Valtorta, Silvia, et al.
Publicado: (2017)

Editorial: Novel therapeutic approaches to target drug resistant tumors
por: Riganti, Chiara, et al.
Publicado: (2023)

SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2022)

Glioblastoma Multiforme
por: Sheehan, Jonas M., et al.
Publicado: (2012)

A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone against Early Renal Dysfunction and Injury Evoked by Ischemia/Reperfusion
por: Chiazza, Fausto, et al.
Publicado: (2015)

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer
por: Riganti, Chiara, et al.
Publicado: (2019)

N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD
por: O'Reilly, Philip, et al.
Publicado: (2009)

Overcoming delivery barriers in immunotherapy for glioblastoma
por: Rui, Yuan, et al.
Publicado: (2021)

Barriers to overcoming immunotherapy resistance in glioblastoma
por: Gillette, Julia S., et al.
Publicado: (2023)

Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme
por: Jena, Lynn, et al.
Publicado: (2019)

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers
por: Braconi, Laura, et al.
Publicado: (2020)

NO in Viral Infections: Role and Development of Antiviral Therapies
por: Sodano, Federica, et al.
Publicado: (2022)

Methotrexate-Loaded Solid Lipid Nanoparticles: Protein Functionalization to Improve Brain Biodistribution
por: Muntoni, Elisabetta, et al.
Publicado: (2019)

Glioblastoma multiforme – an overview
por: Urbańska, Kaja, et al.
Publicado: (2014)

Incidentalomas to glioblastoma multiforme
por: Sachdev, Bobby, et al.
Publicado: (2014)

Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition
por: Gelsomino, Giada, et al.
Publicado: (2013)

A Proteomic Platform Unveils the Brain Glycogen Phosphorylase as a Potential Therapeutic Target for Glioblastoma Multiforme
por: Ferraro, Giusy, et al.
Publicado: (2022)

PGP: Pretty Good Privacy
por: Garfinkel, Simson
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_chut3qq5tje3967ui3reofolbt