Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate

Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine. The chiral hemiacetal fragment is constructed...

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Detalles Bibliográficos
Autores principales: Gao, Haoling, Yu, Jiangang, Ge, Chengsheng, Jiang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099835/
https://www.ncbi.nlm.nih.gov/pubmed/29899310
http://dx.doi.org/10.3390/molecules23061440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099835/
https://www.ncbi.nlm.nih.gov/pubmed/29899310
http://dx.doi.org/10.3390/molecules23061440

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