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Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate
Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine. The chiral hemiacetal fragment is constructed...
Autores principales: | Gao, Haoling, Yu, Jiangang, Ge, Chengsheng, Jiang, Qun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099835/ https://www.ncbi.nlm.nih.gov/pubmed/29899310 http://dx.doi.org/10.3390/molecules23061440 |
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