Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile

Because lysine-specific demethylase 1 (LSD1) regulates the maintenance of cancer stem cell properties, small-molecule inhibitors of LSD1 are expected to be useful for the treatment of several cancers. Reversible inhibitors of LSD1 with submicromolar inhibitory potency have recently been reported, bu...

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Detalles Bibliográficos
Autores principales: Niwa, Hideaki, Sato, Shin, Hashimoto, Tomoko, Matsuno, Kenji, Umehara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099836/
https://www.ncbi.nlm.nih.gov/pubmed/29949906
http://dx.doi.org/10.3390/molecules23071538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099836/
https://www.ncbi.nlm.nih.gov/pubmed/29949906
http://dx.doi.org/10.3390/molecules23071538

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