Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation—The Example of FimH

Located at the tip of type I fimbria of Escherichia coli, the bacterial adhesin FimH is responsible for the attachment of the bacteria to the (human) host by specifically binding to highly-mannosylated glycoproteins located on the exterior of the host cell wall. Adhesion represents a necessary early...

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Detalles Bibliográficos
Autores principales: Krammer, Eva-Maria, de Ruyck, Jerome, Roos, Goedele, Bouckaert, Julie, Lensink, Marc F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099838/
https://www.ncbi.nlm.nih.gov/pubmed/29976867
http://dx.doi.org/10.3390/molecules23071641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099838/
https://www.ncbi.nlm.nih.gov/pubmed/29976867
http://dx.doi.org/10.3390/molecules23071641

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