Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites

Warsaw breakage syndrome, a developmental disorder caused by mutations in the DDX11/ChlR1 helicase, shows cellular features of genome instability similar to Fanconi anemia (FA). Here we report that DDX11-deficient avian DT40 cells exhibit interstrand crosslink (ICL)-induced chromatid breakage, with...

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Detalles Bibliográficos
Autores principales: Abe, Takuya, Ooka, Masato, Kawasumi, Ryotaro, Miyata, Keiji, Takata, Minoru, Hirota, Kouji, Branzei, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099846/
https://www.ncbi.nlm.nih.gov/pubmed/30061412
http://dx.doi.org/10.1073/pnas.1803110115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099846/
https://www.ncbi.nlm.nih.gov/pubmed/30061412
http://dx.doi.org/10.1073/pnas.1803110115

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