Cargando…

Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N

A new directed evolution approach is presented to enhance the activity of an enzyme and to manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) simultaneously on residues lining the entrance tunnel and the binding pocket. This combined mutagenesis strategy was applied succ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Guangyue, Yao, Peiyuan, Gong, Rui, Li, Jinlong, Liu, Pi, Lonsdale, Richard, Wu, Qiaqing, Lin, Jianping, Zhu, Dunming, Reetz, Manfred T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099926/ https://www.ncbi.nlm.nih.gov/pubmed/30155214 http://dx.doi.org/10.1039/c6sc05381e

Ejemplares similares

Correction: Simultaneous engineering of an enzyme’s entrance tunnel and active site: the case of monoamine oxidase MAO-N
por: Li, Guangyue, et al.
Publicado: (2017)

Marine natural products with monoamine oxidase (MAO) inhibitory activity
por: Hong, Ahreum, et al.
Publicado: (2020)

Molecular docking analysis and dynamics simulation of salbutamol with the monoamine oxidase B (MAO-B) enzyme
por: Abdulhameed Odhar, Hasanain, et al.
Publicado: (2022)

New recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates
por: Li, Guangyue, et al.
Publicado: (2016)

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression
por: Kushal, Swati, et al.
Publicado: (2016)

β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO)
por: Herraiz, Tomás
Publicado: (2023)

Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B
por: Chaurasiya, Narayan D., et al.
Publicado: (2014)

Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors
por: Sairam, Kalapatapu V.V.M., et al.
Publicado: (2007)

Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature Analysis
por: Yeung, Andy Wai Kan, et al.
Publicado: (2019)

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development
por: Aljanabi, Reem, et al.
Publicado: (2021)

Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease
por: Teo, Kay Cheong, et al.
Publicado: (2013)

From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression
por: Mentis, Alexios-Fotios A., et al.
Publicado: (2021)

Correction: From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression
por: Mentis, Alexios-Fotios A., et al.
Publicado: (2021)

Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors
por: van Hoogdalem, Ewoud‐Jan, et al.
Publicado: (2023)

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
por: Kaya, Betül, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
por: Turan-Zitouni, Gülhan, et al.
Publicado: (2018)

Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting
por: Sadler, Joanna C., et al.
Publicado: (2018)

Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms
por: Phoswa, Wendy N.
Publicado: (2019)

Monoamine Oxidase (MAO) Is Expressed at the Level of Mitral Valve with Severe Regurgitation in Hypertrophic Obstructive Cardiomyopathy: A Case Report
por: Lascu, Ana, et al.
Publicado: (2022)

Biocatalytic and Chemo-Enzymatic Synthesis of Quinolines and 2-Quinolones by Monoamine Oxidase (MAO-N) and Horseradish Peroxidase (HRP) Biocatalysts
por: Xiang, Haoyue, et al.
Publicado: (2023)

Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction
por: Duan, Yitao, et al.
Publicado: (2015)

A Strategy to Employ Clitoria ternatea as a Prospective Brain Drug Confronting Monoamine Oxidase (MAO) Against Neurodegenerative Diseases and Depression
por: Margret, A. Anita, et al.
Publicado: (2015)

Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol
por: Turkmenoglu, Fatma Pinar, et al.
Publicado: (2015)

Association of variable number of tandem repeats (VNTR) and T941G polymorphism of monoamine oxidase (MAO-A) gene with aggression in Pakistani subjects
por: Sarwar, Sumbal, et al.
Publicado: (2021)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

Green Oxidation of Amines by a Novel Cold-Adapted Monoamine Oxidase MAO P3 from Psychrophilic Fungi Pseudogymnoascus sp. P3
por: Jodłowska, Iga, et al.
Publicado: (2021)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration
por: Tzvetkov, Nikolay T., et al.
Publicado: (2017)

Analysis on the Vulnerability of a Tunnel Entrance under Internal Explosion
por: Liu, Zichao, et al.
Publicado: (2022)

Assessment of contrast perception of obstacles in a tunnel entrance
por: Mehri, Ahmad, et al.
Publicado: (2018)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

AN APPRAISAL OF THE USE OF MONOAMINE OXIDASE AS AN ENZYME MARKER FOR THE OUTER MEMBRANE OF RAT LIVER MITOCHONDRIA
por: Greenawalt, John W., et al.
Publicado: (1970)

Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme
por: Singh, Rajbir, et al.
Publicado: (2020)

Simultaneous Production of Psilocybin and a Cocktail of β‐Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms
por: Blei, Felix, et al.
Publicado: (2019)

Find_tfSBP: find thermodynamics-feasible and smallest balanced pathways with high yield from large-scale metabolic networks
por: Xu, Zixiang, et al.
Publicado: (2017)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
por: Mialet-Perez, Jeanne, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j29bq8ak7gjdmcm78rd55la38h