Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway

The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death in response to various cellular stresses, thereby preventing cancer development. Therefore, the activation of p53 through small molecules is an attractive therapeutic strategy for the treatment of cancers...

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Detalles Bibliográficos
Autores principales: Nagasaka, Mai, Hashimoto, Ryoko, Inoue, Yasumichi, Ishiuchi, Kan’ichiro, Matsuno, Michiyo, Itoh, Yuka, Tokugawa, Muneshige, Ohoka, Nobumichi, Morishita, Daisuke, Mizukami, Hajime, Makino, Toshiaki, Hayashi, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099937/
https://www.ncbi.nlm.nih.gov/pubmed/29890668
http://dx.doi.org/10.3390/molecules23061394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099937/
https://www.ncbi.nlm.nih.gov/pubmed/29890668
http://dx.doi.org/10.3390/molecules23061394

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