Design, Synthesis and Biological Evaluation of Novel Phenylsulfonylurea Derivatives as PI3K/mTOR Dual Inhibitors

Five series of novel phenylsulfonylurea derivatives, 19a–d, 20a–d, 21a–d, 22a–d and 23a–d, bearing 4-phenylaminoquinoline scaffold were designed, synthesized and their IC(50) values against four cancer cell lines (HepG-2, A549, PC-3 and MCF-7) were evaluated. Most compounds showed moderate cytotoxic...

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Detalles Bibliográficos
Autores principales: Zhao, Bingbing, Lei, Fei, Wang, Caolin, Zhang, Binliang, Yang, Zunhua, Li, Wei, Zhu, Wufu, Xu, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099940/
https://www.ncbi.nlm.nih.gov/pubmed/29954109
http://dx.doi.org/10.3390/molecules23071553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099940/
https://www.ncbi.nlm.nih.gov/pubmed/29954109
http://dx.doi.org/10.3390/molecules23071553

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