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Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary libr...

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Detalles Bibliográficos
Autores principales: Méndez, Luciana, Poeylaut-Palena, Andrés A., Mata, Ernesto G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100001/
https://www.ncbi.nlm.nih.gov/pubmed/29772720
http://dx.doi.org/10.3390/molecules23051193