Cargando…

Indole Derivatives as Cyclooxygenase Inhibitors: Synthesis, Biological Evaluation and Docking Studies

A new series of 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N′-[(E)-(substituted phenyl) methylidene] acetohydrazide derivatives (S1–S18) were synthesized and evaluated for their anti-inflammatory activity, analgesic activity, ulcerogenic activity, lipid peroxidation, ulcer index and cyclooxygenase express...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhat, Mashooq Ahmad, Al-Omar, Mohamed A., Raish, Mohammad, Ansari, Mushtaq Ahmad, Abuelizz, Hatem A., Bakheit, Ahmed H., Naglah, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100013/ https://www.ncbi.nlm.nih.gov/pubmed/29882911 http://dx.doi.org/10.3390/molecules23061250

Ejemplares similares

Synthesis and in vivo anti-ulcer evaluation of some novel piperidine linked dihydropyrimidinone derivatives
por: Ahmad Bhat, Mashooq, et al.
Publicado: (2018)

Investigation of some benzoquinazoline and quinazoline derivatives as novel inhibitors of HCV-NS3/4A protease: biological, molecular docking and QSAR studies
por: Abuelizz, Hatem A., et al.
Publicado: (2020)

Synthesis of Novel Sulfamethaoxazole 4-Thiazolidinone Hybrids and Their Biological Evaluation
por: Bhat, Mashooq A., et al.
Publicado: (2020)

Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5-a]pyrimidines
por: Naglah, Ahmed M., et al.
Publicado: (2020)

A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety
por: Bhat, Mashooq Ahmad, et al.
Publicado: (2018)

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane
por: Bhat, Mashooq Ahmad, et al.
Publicado: (2019)

Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Synthesis, Docking, Computational Studies, and Antimicrobial Evaluations of New Dipeptide Derivatives Based on Nicotinoylglycylglycine Hydrazide
por: Khalaf, Hemat S., et al.
Publicado: (2020)

N(α)-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation
por: Naglah, Ahmed M, et al.
Publicado: (2021)

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization
por: Naglah, Ahmed M, et al.
Publicado: (2019)

Evaluation of Some Benzo[g]Quinazoline Derivatives as Antiviral Agents against Human Rotavirus Wa Strain: Biological Screening and Docking Study
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[g]quinazoline Derivatives (In Vitro)
por: Abuelizz, Hatem A., et al.
Publicado: (2020)

Benzo[g]quinazolines as antifungal against candidiasis: Screening, molecular docking, and QSAR investigations
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Antiviral activity of some benzo[g]quinazolines against coxsackievirus B4: biological screening and docking study
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Reactivity of 4,5-Dichlorophthalic Anhydride towards Thiosemicarbazide and Amines: Synthesis, Spectroscopic Analysis, and DFT Study
por: Abuelizz, Hatem A., et al.
Publicado: (2022)

ChCl: Gly (DESs) Promote Environmentally Benign Synthesis of Xanthene Derivatives and Their Antitubercular Activity
por: Bhat, Mashooq A., et al.
Publicado: (2021)

A Novel Oxidovanadium (IV)-Orotate Complex as an Alternative Antidiabetic Agent: Synthesis, Characterization, and Biological Assessments
por: Naglah, Ahmed M., et al.
Publicado: (2018)

Phytochemical Analysis, In Vitro Biological Activities, and Computer-Aided Analysis of Potentilla nepalensis Hook Compounds as Potential Melanoma Inhibitors Based on Molecular Docking, MD Simulations, and ADMET
por: Sharma, Subhash, et al.
Publicado: (2023)

Synthesis, Characterization, and Anti-diabetic Activity of Some Novel Vanadium-Folate-Amino Acid Materials
por: M. Naglah, Ahmed, et al.
Publicado: (2020)

Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Lead Optimization of 2-Cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides for Targeting the HER-2 Overexpressed Breast Cancer Cell Line SKBr-3
por: Bhat, Mashooq A., et al.
Publicado: (2015)

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
por: El-Sayed, Magda A.-A., et al.
Publicado: (2017)

Study of the Interactions of Bovine Serum Albumin with the New Anti-Inflammatory Agent 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N′-[(4-ethoxy-phenyl)methylidene]benzohydrazide Using a Multi-Spectroscopic Approach and Molecular Docking
por: Wani, Tanveer A., et al.
Publicado: (2017)

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity
por: Hassan, Ashraf S., et al.
Publicado: (2020)

Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity
por: Bhat, Mashooq A., et al.
Publicado: (2020)

Biological Evaluation and Docking Analysis of Daturaolone as Potential Cyclooxygenase Inhibitor
por: Rauf, Abdur, et al.
Publicado: (2016)

Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Unfolding the Antibacterial Activity and Acetylcholinesterase Inhibition Potential of Benzofuran-Triazole Hybrids: Synthesis, Antibacterial, Acetylcholinesterase Inhibition, and Molecular Docking Studies
por: Saeed, Sadaf, et al.
Publicado: (2023)

Biological Investigation of 2-Thioxo-benzo[g]quinazolines against Adenovirus Type 7 and Bacteriophage Phi X174: An In Vitro Study
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

In silico and in vitro metabolism of ribociclib: a mass spectrometric approach to bioactivation pathway elucidation and metabolite profiling
por: Alsubi, Thamer A., et al.
Publicado: (2020)

Correction: In silico and in vitro metabolism of ribociclib: a mass spectrometric approach to bioactivation pathway elucidation and metabolite profiling
por: Alsubi, Thamer A., et al.
Publicado: (2020)

New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges
por: Naglah, Ahmed M., et al.
Publicado: (2016)

Molecular docking, pharmacokinetic studies, and in vivo pharmacological study of indole derivative 2-(5-methoxy-2-methyl-1H-indole-3-yl)-N′-[(E)-(3-nitrophenyl) methylidene] acetohydrazide as a promising chemoprotective agent against cisplatin induced organ damage
por: Razak, Suhail, et al.
Publicado: (2021)

Alleviative effects of pinostrobin against cadmium-induced renal toxicity in rats by reducing oxidative stress, apoptosis, inflammation, and mitochondrial dysfunction
por: Ijaz, Muhammad Umar, et al.
Publicado: (2023)

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors
por: Coşkun, Göknil Pelin, et al.
Publicado: (2018)

Toxicity Study and Binding Analysis of Newly Synthesized Antifungal N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide Derivative with Bovine Serum Albumin
por: Wani, Tanveer A., et al.
Publicado: (2023)

Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties
por: Mphahlele, Malose J., et al.
Publicado: (2018)

Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles
por: Hassan, Ashraf S., et al.
Publicado: (2019)

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oa4ib1i2g1g297c1k3ajqbtkhk