Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO(2)) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or its phosphate NAD(P)H, however, it is unclear whi...

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Detalles Bibliográficos
Autores principales: Valiauga, Benjaminas, Misevičienė, Lina, Rich, Michelle H., Ackerley, David F., Šarlauskas, Jonas, Čėnas, Narimantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100041/
https://www.ncbi.nlm.nih.gov/pubmed/29987261
http://dx.doi.org/10.3390/molecules23071672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100041/
https://www.ncbi.nlm.nih.gov/pubmed/29987261
http://dx.doi.org/10.3390/molecules23071672

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