Cargando…

Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent recurrence even after curative treatment. Thus, an effective and safe long-term chemopreventive agent is strongly in demand. Menahydroquinone-4 (MKH) is an active form of menaquinone-4 (MK-4, vitamin K(2)) that is involve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Setoguchi, Shuichi, Watase, Daisuke, Matsunaga, Kazuhisa, Yamakawa, Hirofumi, Goto, Shotaro, Terada, Kazuki, Ohe, Kenji, Enjoji, Munechika, Karube, Yoshiharu, Takata, Jiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100056/ https://www.ncbi.nlm.nih.gov/pubmed/30013007 http://dx.doi.org/10.3390/molecules23071738

Ejemplares similares

Menahydroquinone-4 Prodrug: A Promising Candidate Anti-Hepatocellular Carcinoma Agent
por: Enjoji, Munechika, et al.
Publicado: (2015)

Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K(2(20)), Could Overcome the Photoinstability and Phototoxicity of Vitamin K(2(20))
por: Goto, Shotaro, et al.
Publicado: (2019)

Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K(2(20)), on All-Trans Retinoic Acid-Resistant HL60 Cell Line
por: Yamakawa, Hirofumi, et al.
Publicado: (2021)

Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion
por: Watase, Daisuke, et al.
Publicado: (2022)

Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study
por: Terada, Kazuki, et al.
Publicado: (2020)

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions
por: Setoguchi, Shuichi, et al.
Publicado: (2020)

Delivery of the reduced form of vitamin K(2(20)) to NIH/3T3 cells partially protects against rotenone induced cell death
por: Toki, Erina, et al.
Publicado: (2022)

Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors
por: Terada, Kazuki, et al.
Publicado: (2018)

Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H(2)S biomedicine
por: Zhu, Yaoqiu, et al.
Publicado: (2018)

Oxytocin treatment improves dexamethasone‐induced depression‐like symptoms associated with enhancement of hippocampal CREB‐BDNF signaling in female mice
por: Mori, Masayoshi, et al.
Publicado: (2022)

Author Correction: Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H(2)S biomedicine
por: Zhu, Yaoqiu, et al.
Publicado: (2018)

NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease
por: Enjoji, Munechika, et al.
Publicado: (2010)

Recovery Sleep Immediately after Prolonged Sleep Deprivation Stimulates the Transcription of Integrated Stress Response-Related Genes in the Liver of Male Rats
por: Fukuoka, Keisuke, et al.
Publicado: (2022)

Unfolding and Refolding of Protein by a Combination of Ionic and Nonionic Surfactants
por: Saha, Debasish, et al.
Publicado: (2018)

Leptin attenuates D(2) receptor‐mediated inhibition of putative ventral tegmental area dopaminergic neurons
por: Murakami, Takami, et al.
Publicado: (2018)

Modified activity-based anorexia paradigm dampens chronic food restriction-induced hyperadiponectinemia in adolescent female mice
por: Kuriyama, Toru, et al.
Publicado: (2023)

Nutrition and Nonalcoholic Fatty Liver Disease: The Significance of Cholesterol
por: Enjoji, Munechika, et al.
Publicado: (2012)

Metabolic Disorders and Steatosis in Patients with Chronic Hepatitis C: Metabolic Strategies for Antiviral Treatments
por: Enjoji, Munechika, et al.
Publicado: (2012)

Transforming Growth Factor‐α Induces the Differentiation of Sarcomatoid Cholangiocarcinoma Cells
por: Enjoji, Munechika, et al.
Publicado: (2000)

Observation of Strong Synergy in the Interfacial Water Response of Binary Ionic and Nonionic Surfactant Mixtures
por: Sengupta, Sanghamitra, et al.
Publicado: (2022)

Assessing the Location of Ionic and Molecular Solutes in a Molecularly Heterogeneous and Nonionic Deep Eutectic Solvent
por: Chen, Xiaobing, et al.
Publicado: (2020)

Polymerization of aniline hydrochloride in reverse of microemulsion by batch and semicontinuous process using ionic and nonionic surfactants
por: Pier Villegas, G., et al.
Publicado: (2022)

Refolding of SDS-Unfolded Proteins by Nonionic Surfactants
por: Kaspersen, Jørn Døvling, et al.
Publicado: (2017)

Changes in the Penetration Rate of Biosimilar Infliximab Within Japan Using a Japanese Claims Database
por: Matsumoto, Tsugumi, et al.
Publicado: (2021)

Association between Nonionic Amphiphilic Polymer and Ionic Surfactant in Aqueous Solutions: Effect of Polymer Hydrophobicity and Micellization †
por: Kancharla, Samhitha, et al.
Publicado: (2020)

The Cheshire cat phenomenon: effects of nonionizing electromagnetic radiation.
por: Pinholster, G
Publicado: (1993)

QSPR Modeling of Bioconcentration Factors of Nonionic Organic Compounds
por: Deeb, Omar, et al.
Publicado: (2010)

2-Ethylhexanol Derivatives as Nonionic Surfactants: Synthesis and Properties
por: Hreczuch, Wiesław, et al.
Publicado: (2015)

Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel
por: Lo, Jen-Ting, et al.
Publicado: (2016)

Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures
por: Aramaki, Kenji, et al.
Publicado: (2020)

Simultaneous thermal analysis of cationic, nonionic and anionic polyacrylamide
por: Steudel, Annett, et al.
Publicado: (2019)

Oil-Tolerant Nonionic Worm-like Micellar Solution
por: Panthi, Krishna, et al.
Publicado: (2020)

Nonionizing Electromagnetic Irradiations; Biological Interactions, Human Safety
por: Akbari, Hamed, et al.
Publicado: (2023)

Investigation of the Nonionic Acidizing Retarder AAO for Reservoir Stimulation
por: Chen, Zhonghao, et al.
Publicado: (2023)

Arylazo Sulfones as Nonionic Visible-Light Photoacid Generators
por: Di Terlizzi, Lorenzo, et al.
Publicado: (2022)

Soil flushing of cresols contaminated soil: application of nonionic and ionic surfactants under different pH and concentrations
por: Gitipour, Saeid, et al.
Publicado: (2014)

Desorption of hydrocarbon chains by association with ionic and nonionic surfactants under flow as a mechanism for enhanced oil recovery
por: Terrón-Mejía, Ketzasmin A., et al.
Publicado: (2017)

The Influence of Ionic and Nonionic Surfactants on the Colloidal Stability and Removal of CuO Nanoparticles from Water by Chemical Coagulation
por: Khan, Rizwan, et al.
Publicado: (2019)

A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study
por: Kotoh, Kazuhiro, et al.
Publicado: (2008)

Nutrition Therapy for Liver Diseases Based on the Status of Nutritional Intake
por: Yasutake, Kenichiro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_d7l721hlqc1cm34lh4gmgbs30i