Design, Synthesis, and Evaluation of Homochiral Peptides Containing Arginine and Histidine as Molecular Transporters

Linear (HR)(n) and cyclic [HR](n) peptides (n = 4,5) containing alternate arginine and histidine residues were synthesized. The peptides showed 0–15% cytotoxicity at 5–100 µM in human ovarian adenocarcinoma (SK-OV-3) cells while they exhibited 0–12% toxicity in human leukemia cancer cell line (CCRF-...

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Detalles Bibliográficos
Autores principales: El-Sayed, Naglaa Salem, Miyake, Taryn, Shirazi, Amir Nasrolahi, Park, Shang Eun, Clark, Jimmy, Buchholz, Stephani, Parang, Keykavous, Tiwari, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100079/
https://www.ncbi.nlm.nih.gov/pubmed/29966296
http://dx.doi.org/10.3390/molecules23071590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100079/
https://www.ncbi.nlm.nih.gov/pubmed/29966296
http://dx.doi.org/10.3390/molecules23071590

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