Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Compound-3 is an oral monophosphate prodrug of gemcitabine. Previous data showed that Compound-3 was more potent than gemcitabine and it was orally active in a tumor xenograft model. In the present study, the metabolism of Compound-3 was investigated in several well-known in vitro matrices. While re...

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Detalles Bibliográficos
Autores principales: Wang, Yedong, Li, Yuan, Lu, Jia, Qi, Huixin, Cheng, Isabel, Zhang, Hongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100113/
https://www.ncbi.nlm.nih.gov/pubmed/29772747
http://dx.doi.org/10.3390/molecules23051195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100113/
https://www.ncbi.nlm.nih.gov/pubmed/29772747
http://dx.doi.org/10.3390/molecules23051195

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