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Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

Compound-3 is an oral monophosphate prodrug of gemcitabine. Previous data showed that Compound-3 was more potent than gemcitabine and it was orally active in a tumor xenograft model. In the present study, the metabolism of Compound-3 was investigated in several well-known in vitro matrices. While re...

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Detalles Bibliográficos
Autores principales:	Wang, Yedong, Li, Yuan, Lu, Jia, Qi, Huixin, Cheng, Isabel, Zhang, Hongjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100113/ https://www.ncbi.nlm.nih.gov/pubmed/29772747 http://dx.doi.org/10.3390/molecules23051195

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