Phosphorus Pentachloride Promoted gem-Dichlorination of 2′- and 3′-Deoxynucleosides

Halogen substitution at various positions of canonical nucleosides has generated a number of bioactive structural variants. Herein, the synthesis of two unique series of sugar modified nucleosides bearing a gem-dichloro group is presented. The synthetic plan entails the controlled addition of phosph...

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Detalles Bibliográficos
Autores principales: da Paixao Soares, Fabio, Groaz, Elisabetta, Herdewijn, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100136/
https://www.ncbi.nlm.nih.gov/pubmed/29914115
http://dx.doi.org/10.3390/molecules23061457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100136/
https://www.ncbi.nlm.nih.gov/pubmed/29914115
http://dx.doi.org/10.3390/molecules23061457

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