Insights into Resistance Mechanisms of Inhibitors to Mps1 C604Y Mutation via a Comprehensive Molecular Modeling Study

Mono-polar spindle 1 (Mps1/TTK) represents a protein kinase reported to be vital for cell division processes and is generally regarded as an attractive target for the treatment of hepatocellular carcinoma, breast carcinoma, and colon cancer. However, the C604Y mutation has been linked to acquired re...

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Detalles Bibliográficos
Autores principales: Chen, Yuan, Yu, Wenquan, Jiang, Cui-cui, Zheng, Jin-gui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100145/
https://www.ncbi.nlm.nih.gov/pubmed/29925769
http://dx.doi.org/10.3390/molecules23061488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100145/
https://www.ncbi.nlm.nih.gov/pubmed/29925769
http://dx.doi.org/10.3390/molecules23061488

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