Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP

The calcium-dependent β-propeller proteins mammalian serum paraoxonase 1 (PON1) and phosphotriesterase diisopropyl fluorophosphatase (DFPase) catalyze the hydrolysis of organophosphorus compounds and enhance hydrolysis of various nerve agents. In the present work, the phosphotriesterase activity dev...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Yang, Ling, Ma, Ying-Ying, Zhu, Chaoyuan, Lin, Shenghsien, Liao, Rong-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100192/
https://www.ncbi.nlm.nih.gov/pubmed/29986514
http://dx.doi.org/10.3390/molecules23071660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100192/
https://www.ncbi.nlm.nih.gov/pubmed/29986514
http://dx.doi.org/10.3390/molecules23071660

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