Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity

A series of novel 2,4-diaminoquinazoline derivatives were designed, synthesized, and evaluated as p21-activated kinase 4 (PAK4) inhibitors. All compounds showed significant inhibitory activity against PAK4 (half-maximal inhibitory concentration IC(50) < 1 μM). Among them, compounds 8d and 9c demo...

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Detalles Bibliográficos
Autores principales: Wu, Tianxiao, Pang, Yu, Guo, Jing, Yin, Wenbo, Zhu, Mingyue, Hao, Chenzhou, Wang, Kai, Wang, Jian, Zhao, Dongmei, Cheng, Maosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100240/
https://www.ncbi.nlm.nih.gov/pubmed/29443911
http://dx.doi.org/10.3390/molecules23020417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100240/
https://www.ncbi.nlm.nih.gov/pubmed/29443911
http://dx.doi.org/10.3390/molecules23020417

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