High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans

Protein tyrosine phosphatase 1B (PTP1B) is an intracellular enzyme responsible for deactivation of the insulin receptor, and consequently acts as a negative regulator of insulin signal transduction. In recent years, PTP1B has become an important target for controlling insulin resistance and type 2 d...

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Detalles Bibliográficos
Autores principales: de Cássia Lemos Lima, Rita, T. Kongstad, Kenneth, Kato, Lucília, José das Silva, Marcos, Franzyk, Henrik, Staerk, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100288/
https://www.ncbi.nlm.nih.gov/pubmed/30018269
http://dx.doi.org/10.3390/molecules23071755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100288/
https://www.ncbi.nlm.nih.gov/pubmed/30018269
http://dx.doi.org/10.3390/molecules23071755

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