Synthesis and PI 3-Kinase Inhibition Activity of Some Novel 2,4,6-Trisubstituted 1,3,5-Triazines

A number of new trisubstituted triazine phosphatidylinositol 3-kinase (PI3K) inhibitors were prepared via a three-step procedure utilizing sequential nucleophilic aromatic substitution and cross-coupling reactions. All were screened as PI3K inhibitors relative to the well-characterized PI3K inhibito...

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Detalles Bibliográficos
Autores principales: Nelson, Ronald A., Schronce, Taylor, Huang, Yue, Albugami, Alanoud, Kulik, George, Welker, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100378/
https://www.ncbi.nlm.nih.gov/pubmed/29973512
http://dx.doi.org/10.3390/molecules23071628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100378/
https://www.ncbi.nlm.nih.gov/pubmed/29973512
http://dx.doi.org/10.3390/molecules23071628

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