Preparation of Novel Homodimers Derived from Cytotoxic Isoquinolinequinones. A Twin Drug Approach

The synthesis of five novel homodimers is reported based on the anilinoisoquinolinequinone scaffold. In these twin-drug derivatives, two units of the anilinoquinone pharmacophores are linked through a methylene spacer. The formation of dimers was achieved by reaction of isoquinolinequinones with 4,...

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Detalles Bibliográficos
Autores principales: Ibacache, Juana Andrea, Faundes, Judith, Montoya, Margarita, Mejías, Sophia, Valderrama, Jaime A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100386/
https://www.ncbi.nlm.nih.gov/pubmed/29462956
http://dx.doi.org/10.3390/molecules23020439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100386/
https://www.ncbi.nlm.nih.gov/pubmed/29462956
http://dx.doi.org/10.3390/molecules23020439

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