Cargando…

Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity

Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2 diabetes etiology, resulting from FA overload, oxidative stress, intermediate hyperinsulinemia, and inflammation, all converging into insulin resistance. Focusing on pancreatic islet β-cells, we compare the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ježek, Petr, Jabůrek, Martin, Holendová, Blanka, Plecitá-Hlavatá, Lydie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100479/ https://www.ncbi.nlm.nih.gov/pubmed/29921789 http://dx.doi.org/10.3390/molecules23061483

Ejemplares similares

Contribution of Mitochondria to Insulin Secretion by Various Secretagogues
por: Ježek, Petr, et al.
Publicado: (2022)

The Pancreatic β-Cell: The Perfect Redox System
por: Ježek, Petr, et al.
Publicado: (2021)

Redox Signaling from Mitochondria: Signal Propagation and Its Targets
por: Ježek, Petr, et al.
Publicado: (2020)

Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
por: Ježek, Petr, et al.
Publicado: (2019)

Cysteine residues in signal transduction and its relevance in pancreatic beta cells
por: Holendova, Blanka, et al.
Publicado: (2023)

Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
por: Benáková, Štěpánka, et al.
Publicado: (2021)

Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD(+) Ratio
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2020)

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid–Conducting SLC25 Gene Family Transporters
por: Jabůrek, Martin, et al.
Publicado: (2021)

Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic β-cells
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2019)

Redox Homeostasis in Pancreatic β Cells
por: Ježek, Petr, et al.
Publicado: (2012)

Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia
por: Ježek, Jan, et al.
Publicado: (2018)

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling
por: Ježek, Petr, et al.
Publicado: (2018)

Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
por: Ježek, Petr, et al.
Publicado: (2023)

H(2)O(2)-Activated Mitochondrial Phospholipase iPLA(2)γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein–Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells
por: Ježek, Jan, et al.
Publicado: (2015)

Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca(2+)-Independent Phospholipase A(2)γ in the Brain
por: Průchová, Pavla, et al.
Publicado: (2022)

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
por: D'Alessandro, Angelo, et al.
Publicado: (2018)

Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen
por: Jabůrek, Martin, et al.
Publicado: (2018)

The role of m(6)A and m(6)Am RNA modifications in the pathogenesis of diabetes mellitus
por: Benak, Daniel, et al.
Publicado: (2023)

Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2
por: Malingriaux, Elena A., et al.
Publicado: (2013)

Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
por: Kahancová, Anežka, et al.
Publicado: (2020)

Role of 3-Hydroxy Fatty Acid-Induced Hepatic Lipotoxicity in Acute Fatty Liver of Pregnancy
por: Natarajan, Sathish Kumar, et al.
Publicado: (2018)

Improvement of Lipotoxicity-Induced Islet β Cellular Insulin Secretion Disorder by Osteocalcin
por: Zhang, Yafang, et al.
Publicado: (2022)

Non-alcoholic fatty liver disease and lipotoxicity
por: Wasilewska, Natalia, et al.
Publicado: (2021)

Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids
por: Chlenski, Alexandre, et al.
Publicado: (2016)

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2
por: Smolková, Katarína, et al.
Publicado: (2020)

Novel Insights and Mechanisms of Lipotoxicity-Driven Insulin Resistance
por: Lair, Benjamin, et al.
Publicado: (2020)

Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids
por: Urso, C.J., et al.
Publicado: (2021)

Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
por: Jang, Hee-Seong, et al.
Publicado: (2020)

Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy
por: Yuan, Yuhao, et al.
Publicado: (2021)

Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells
por: Hong, Seok-Woo, et al.
Publicado: (2020)

Glucose-Induced Expression of DAPIT in Pancreatic β-Cells
por: Leguina-Ruzzi, Alberto, et al.
Publicado: (2020)

Hypoxic Signaling and Cholesterol Lipotoxicity in Fatty Liver Disease Progression
por: Tirosh, Oren
Publicado: (2018)

PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid ω-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease
por: Hardwick, James P., et al.
Publicado: (2009)

The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells
por: Plötz, Thomas, et al.
Publicado: (2016)

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids
por: Estadella, Débora, et al.
Publicado: (2013)

Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro
por: Elbaz, Alexandre, et al.
Publicado: (2010)

Hepatic Choline Transport Is Inhibited During Fatty Acid–Induced Lipotoxicity and Obesity
por: O’Dwyer, Conor, et al.
Publicado: (2020)

Peroxisome Deficiency Dysregulates Fatty Acid Oxidization and Exacerbates Lipotoxicity in β Cells
por: Guan, Hongbo, et al.
Publicado: (2021)

Stimulation of leptin secretion by insulin
por: Tsai, Minglun, et al.
Publicado: (2012)

Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy
por: Drosatos, Konstantinos
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_51vgdrj04euk5qiapaso8r0sas