Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases

Aberrant activations of the STAT3 (signal transducer and activator of transcription 3) signaling pathway are associated with cancer and inflammatory diseases. Three of the four Janus kinases, JAK1, JAK2, and Tyk2, are the major upstream kinases of STAT3 in responses to cytokine stimulations. Among t...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Man, Xiao, Chengqian, Sun, Mingwei, Tan, Minjia, Hu, Lihong, Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100543/
https://www.ncbi.nlm.nih.gov/pubmed/29921758
http://dx.doi.org/10.3390/molecules23061478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100543/
https://www.ncbi.nlm.nih.gov/pubmed/29921758
http://dx.doi.org/10.3390/molecules23061478

Ejemplares similares