Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization

Some fluoroquinazolinones (A–H) were designed, synthesized and biologically evaluated for their antitumor activity against the two cell lines, MCF-7 and MDA-MBA-231. New derivative G (IC(50) = 0.44 ± 0.01 µM) showed antitumor activity, better than that of the reference drug erlotinib (IC(50) = 1.14...

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Detalles Bibliográficos
Autores principales: Zayed, Mohamed F., Rateb, Heba S., Ahmed, Sahar, Khaled, Osama A., Ibrahim, Sabrin R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100557/
https://www.ncbi.nlm.nih.gov/pubmed/30002297
http://dx.doi.org/10.3390/molecules23071699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100557/
https://www.ncbi.nlm.nih.gov/pubmed/30002297
http://dx.doi.org/10.3390/molecules23071699

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