Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1–10) were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma, and NIH/3T3 (healthy) mouse embryonic fibroblast cell lines. The most potent compounds were...

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Detalles Bibliográficos
Autores principales: Altıntop, Mehlika Dilek, Sever, Belgin, Akalın Çiftçi, Gülşen, Özdemir, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100633/
https://www.ncbi.nlm.nih.gov/pubmed/29857484
http://dx.doi.org/10.3390/molecules23061318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100633/
https://www.ncbi.nlm.nih.gov/pubmed/29857484
http://dx.doi.org/10.3390/molecules23061318

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