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PKCα integrates spatiotemporally distinct Ca(2+) and autocrine BDNF signaling to facilitate synaptic plasticity
The Protein Kinase C (PKC) enzymes have long been established as critical for synaptic plasticity. However, it is unknown whether Ca(2+)-dependent PKC isozymes are activated in dendritic spines during plasticity, and if so, how this synaptic activity is encoded by PKC. Here, using newly-developed, i...
Autores principales: | Colgan, Lesley A, Hu, Mo, Misler, Jaime A, Parra-Bueno, Paula, Moran, Corey M, Leitges, Michael, Yasuda, Ryohei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100743/ https://www.ncbi.nlm.nih.gov/pubmed/30013171 http://dx.doi.org/10.1038/s41593-018-0184-3 |
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