Deep analysis of acquired resistance to FGFR1 inhibitor identifies MET and AKT activation and an expansion of AKT1 mutant cells

The development of acquired resistance (AR) to tyrosine kinase inhibitors (TKIs) of FGFR1 activation is currently not well understood. To gain a deeper insight into this matter in lung cancer, we used the FGFR1-amplified DMS114 cell line and generated multiple clones with AR to an FGFR1-TKI. We mole...

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Detalles Bibliográficos
Autores principales: Gimenez-Xavier, Pol, Pros, Eva, Aza, Ana, Moran, Sebastian, Tonda, Raul, Esteve-Codina, Anna, Dabad, Marc, Sanchez-Cespedes, Montse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101141/
https://www.ncbi.nlm.nih.gov/pubmed/30140389
http://dx.doi.org/10.18632/oncotarget.25862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101141/
https://www.ncbi.nlm.nih.gov/pubmed/30140389
http://dx.doi.org/10.18632/oncotarget.25862

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